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Migraine: identify changes in the brain of people who suffer from it

Migraine is a complicated disease. It not only causes unbearable headaches, but can also cause dizziness, visual disturbances (known as aura), photosensitivity, and even nausea and vomiting. To date, its cause is unknown, and there is no cure.
According to the American Migraine Foundation, an organization that researches this condition, up to 148 million people worldwide suffer from it chronically.
Recently, a team of researchers discovered changes in the brains of people who suffer from migraines. They found that perivascular spaces, fluid-filled spaces around the brain's blood vessels, are larger in people who suffer from both chronic and episodic migraines.
Its relationship with migraine and its role in it have not yet been established. This discovery could represent an unexplored avenue for future research.
To conduct this study, the scientists selected 20 people between the ages of 25 and 60 who suffered from migraines. Of these 20, 10 suffered from chronic migraines and the other 10 from episodic migraines. They also included five healthy patients who did not suffer from migraines as a control group.
The scans showed that the perivascular spaces of people with migraines were much larger than those without the condition.
The researchers also observed a difference in the distribution of a type of lesion known as white matter hyperintensities in migraine patients. These hyperintensities are caused by small patches of dead tissue caused by restricted blood flow and are quite normal. No differences in the frequency of these lesions were observed between people with and without migraines.
Scientists believe that the enlargement of perivascular spaces could lead to the future development of more white matter lesions.
Although the relationship between enlarged perivascular spaces and migraine is unclear, the results suggest that migraines are accompanied by a problem with the brain's plumbing: the glymphatic system, responsible for waste removal in the brain and nervous system. This system uses perivascular channels for transport. More work is needed to explore this correlation, but its identification alone could be promising.

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